The neaSCOPE microscopesare designed for imaging and spectroscopy and for non-invasive analysis of the organization and morphology of biological samples with a spatial resolution of 10 nm.
DNA distribution in white blood cells
The IR image obtained with the neaSCOPE microscope shows a map of protein and DNA rich areas in white blood cells (WBC) overlaid by topography. nano-FTIR spectra in the thinner region (blue) show characteristic bands for single- and double-stranded DNA, indicating that this region is a nuclear pore. The thicker regions show no signs of nucleic acid bands, indicating protein-rich interphase chromosome regions, which are often associated with the development of diseases such as Hodgkin's lymphoma.
Learn more about this and other applications here.