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Molecular staggering in collagen fibers

  • Application description
  • neaSCOPE product line

Research of molecular staggering in collagen fibers

The revolutionary technology of neaSCOPE microscopes provides unprecedented measurement sensitivity, which allows the analysis of a single molecule using low power, so that no fragile biological matter is damaged. This makes it possible to map the composition and organization of complex biological structures at the nanoscale.

Analysis of individual collagen fibers: AFM image, absorption and collagen molecule in detail

Collagen fiber structure

The high-resolution IR image of a single collagen fibril in a mammalian tendon clearly distinguishes the characteristic structure of D-banding with a period of 67 nm associated with the orientation of the amide group. Changes in this area indicate stress, while its absence indicates poor surface shell arrangement and is typical of overload damage. IR nanoscopy thus provides essential information about diseases associated with the destruction and aggregation of proteins at the most basic level.

You can find out more about this and other applications here.

IR-neaSCOPE is the basic model for infrared imaging and nano-spectroscopy. It provides maximum performance without damaging the sample. This is a cost-effective solution for samples with a high coefficient of thermal expansion.
IR-neaSCOPE+fs is designed for pump-probe spectroscopy with 10fs temporal and 10nm spatial resolution: it enables ultra-fast nanoscale science.
IR-neaSCOPE+s enables IR imaging and nano-FTIR spectroscopy by detecting radiation reflected from a standard AFM tip. It is a universal solution for all types of materials. It measures both absorbed and reflected radiation simultaneously and uses the fastest and most reliable modules for nano-imaging and nano-spectroscopy.
IR-neaSCOPE+TERs is a revolution in nano-spectroscopy thanks to a combination of nano-FTIR and Raman spectroscopy techniques, providing complete spectral analysis.

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