Research of molecular staggering in collagen fibers
The revolutionary technology of neaSCOPE microscopes provides unprecedented measurement sensitivity, which allows the analysis of a single molecule using low power, so that no fragile biological matter is damaged. This makes it possible to map the composition and organization of complex biological structures at the nanoscale.
Collagen fiber structure
The high-resolution IR image of a single collagen fibril in a mammalian tendon clearly distinguishes the characteristic structure of D-banding with a period of 67 nm associated with the orientation of the amide group. Changes in this area indicate stress, while its absence indicates poor surface shell arrangement and is typical of overload damage. IR nanoscopy thus provides essential information about diseases associated with the destruction and aggregation of proteins at the most basic level.
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