{"id":9303,"date":"2021-10-06T12:13:07","date_gmt":"2021-10-06T12:13:07","guid":{"rendered":"https:\/\/nicoletcz.cz\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/"},"modified":"2021-10-06T12:13:52","modified_gmt":"2021-10-06T12:13:52","slug":"analysis-of-nicotine-patches","status":"publish","type":"page","link":"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/","title":{"rendered":"Analysis of nicotine patches"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"9303\" class=\"elementor elementor-9303 elementor-9132\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-69a0548 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"69a0548\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8012df8\" data-id=\"8012df8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-104c1ca elementor-widget elementor-widget-eael-adv-tabs\" data-id=\"104c1ca\" data-element_type=\"widget\" data-widget_type=\"eael-adv-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div data-scroll-on-click=\"no\" data-scroll-speed=\"300\" id=\"eael-advance-tabs-104c1ca\" class=\"eael-advance-tabs eael-tabs-horizontal eael-tab-auto-active  active-caret-on responsive-vertical-layout\" data-tabid=\"104c1ca\">\n            <div class=\"eael-tabs-nav\">\n                <ul class=\"\" role=\"tablist\">\n                                            <li id=\"application-description\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"application-description-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Application description<\/span>                                                    <\/li>\n                                            <li id=\"raman-spectroscopy\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"raman-spectroscopy-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Raman spectroscopy<\/span>                                                    <\/li>\n                                            <li id=\"other\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"other-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Other<\/span>                                                    <\/li>\n                                    <\/ul>\n            <\/div>\n            \n            <div class=\"eael-tabs-content\">\n\t\t        \n                    <div id=\"application-description-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"application-description-tab\">\n\t\t\t\t        <p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignright wp-image-9139\" src=\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/78d00216-300x231.jpg\" alt=\"\" width=\"500\" height=\"385\" srcset=\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/78d00216-300x231.jpg 300w, https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/78d00216-1024x788.jpg 1024w, https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/78d00216-768x591.jpg 768w, https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/78d00216.jpg 1200w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/> <strong>Transdermal patches<\/strong>are one way to provide a controlled release of drugs through the skin into the bloodstream via controlled release. <strong>Nicotine patches<\/strong>are one form of treatment for nicotine addiction.<\/p>\n<p>The nicotine transdermal patch itself consists of several layers: a protective layer, an adhesive layer, a membrane and a protective pad. The protective layer serves to protect the adhesive layer and the active substances which are stored in the membrane. The protective pad then serves in particular to protect the other layers while the patch is being applied. For quality control and analysis of the dynamics and mechanism of release of active substances, it is essential to know the exact folded patches, traditional methods of analysis are lengthy and destructive and the patch cannot be used for further measurements (eg CG-MS, LC-MS, SEM, TEM). Therefore, the use of <a href=\"https:\/\/assets.thermofisher.com\/TFS-Assets\/MSD\/Application-Notes\/AN52984-Confocal-Raman-Analysis-Transdermal-Nicotine-Patch.pdf\">confocal <strong>Raman spectroscopy<\/strong><\/a> and a <a href=\"https:\/\/nicoletcz.cz\/en\/product\/dxr3-microscope\/\">Nicolet DXR3<\/a>or <a href=\"https:\/\/nicoletcz.cz\/en\/product\/dxr3xi-microscope\/\">DXR3xi<\/a>microscope is a very elegant way to solve this problem.<\/p>\n<p><figure id=\"attachment_9141\" aria-describedby=\"caption-attachment-9141\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-9141\" src=\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/539faf59-300x194.jpg\" alt=\"\" width=\"600\" height=\"388\" srcset=\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/539faf59-300x194.jpg 300w, https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/539faf59-1024x662.jpg 1024w, https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/539faf59-768x497.jpg 768w, https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/539faf59.jpg 1452w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-9141\" class=\"wp-caption-text\">(a) 2D map: depth profile of the patch obtained using the OMNIC program. The vertical lines show the bands of the Raman spectrum, a total of six different layers with different thicknesses and compositions were identified. (b) Optical cross-sectional image of the sample, providing confirmation of the thicknesses of the individual layers, although the optical contrast is not always convincing. It is used for comparison with the result of depth profiling of the sample.<\/figcaption><\/figure><figure id=\"attachment_9143\" aria-describedby=\"caption-attachment-9143\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-9143\" src=\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/1377159f-300x132.png\" alt=\"\" width=\"600\" height=\"265\" srcset=\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/1377159f-300x132.png 300w, https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/1377159f-1024x452.png 1024w, https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/1377159f-768x339.png 768w, https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/1377159f.png 1429w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-9143\" class=\"wp-caption-text\">Raman spectra of each of the depth profile layers. Their identification was performed by comparing the measured spectra with the spectra of Raman spectra libraries.<\/figcaption><\/figure><\/p>\n<p>The first layer was identified as PET (polyethylene terephthalate). The second and fourth layers contain microporous PE (polyethylene) gradually releasing nicotine, which is contained in the ethylene\/vinyl acetate copolymer (EVA) in the third layer. The fifth layer (adhesive) is polyisobutylene (PIB) and again PET. It can be seen in Figure 4 that the third layer (EVA) serves as a nicotine reservoir. These identification analyzes can be performed using the patented multicomponent search function without the need to modify the measured spectra. Not only did the analysis identify nicotine in a given layer (green in Figure 4), but it also determined its relative spectral representation of the component relative to the second component (EVA, orange). Representation is not directly applicable for quantitative chemical analysis.<\/p>\n<p>Many of the techniques currently used for the analysis of similar samples are time consuming and often destructive. Raman spectroscopy &#8211; in addition to being non-destructive in a well-chosen experiment, it is also a fast technique, and thus allows monitoring of a number of processes that are not observable by other techniques. In combination with a number of sophisticated algorithms, it becomes an irreplaceable part of every modern laboratory.<\/p>\n                    <\/div>\n\t\t        \n                    <div id=\"raman-spectroscopy-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"raman-spectroscopy-tab\">\n\t\t\t\t        <style>@media(max-width:1024px){.elementor-6769 .elementor-element.elementor-element-8179397 .dce-post-item{padding:0px 0px 20px 0px;}}@media(max-width:767px){.elementor-6769 .elementor-element.elementor-element-8179397 .dce-post-item{padding:0px 0px 15px 0px;}}<\/style>\t\t<div data-elementor-type=\"section\" data-elementor-id=\"6769\" class=\"elementor elementor-6769 elementor-4972\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-aa1571b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"aa1571b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4f9ab22\" data-id=\"4f9ab22\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"dce-fix-background-loop elementor-element elementor-element-8179397 templatemode-yes elementor-widget elementor-widget-dyncontel-acfposts\" data-id=\"8179397\" data-element_type=\"widget\" data-widget_type=\"dyncontel-acfposts.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"acfposts-grid dce-posts-wrap simple-style\" data-style=\"simple\">\n\n\t\t\t\t\n\t\t\t\t\t<div data-dce-post-id=\"6678\" class=\"dce-post-item dce-post-item-6678 dce-elementor-6678 elementor-1449 column-  \">\n\n\t\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"dce-wrapper \">\n\n\t\t\t\t\t\t\t\t\t<div data-elementor-type=\"single-post\" data-elementor-id=\"6765\" class=\"elementor elementor-6765 dce-elementor-rendering-id-1 elementor-4983\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2bad051 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2bad051\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0824a49\" data-id=\"0824a49\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-34b4766 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"34b4766\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-699df8e\" data-id=\"699df8e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd1a7f1 dce_masking-none elementor-widget elementor-widget-image\" data-id=\"fd1a7f1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/nicoletcz.cz\/en\/product\/dxr3-microscope\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/nicoletcz.cz\/app\/uploads\/elementor\/thumbs\/46cdeec8-pv2c07lcqh9qz7lya5meayoidxjpy2w41w8yc7yda0.jpg\" title=\"DXXmikr1-468&#215;405 (1)\" alt=\"DXXmikr1-468x405 (1)\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-88ad3bd\" data-id=\"88ad3bd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d504789 elementor-widget elementor-widget-heading\" data-id=\"d504789\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/nicoletcz.cz\/en\/product\/dxr3-microscope\/\">DXR3 Microscope<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-11ea6dc elementor-widget elementor-widget-text-editor\" data-id=\"11ea6dc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tThe Nicolet DXR3 Dispersi Raman Microscope is an instrument designed for applications requiring high spatial resolution, ease of sample preparation, and the use of the strongpoints of Raman microscopy.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div><!-- end wrapper -->\n\n\t\t\t\t\t<\/div><!-- end item -->\n\n\t\t\t\t\t\n\t\t\t\t\t<div data-dce-post-id=\"6673\" class=\"dce-post-item dce-post-item-6673 dce-elementor-6673 elementor-1451 column-  \">\n\n\t\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"dce-wrapper \">\n\n\t\t\t\t\t\t\t\t\t<div data-elementor-type=\"single-post\" data-elementor-id=\"6765\" class=\"elementor elementor-6765 dce-elementor-rendering-id-2 elementor-4983\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2bad051 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2bad051\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0824a49\" data-id=\"0824a49\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-34b4766 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"34b4766\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-699df8e\" data-id=\"699df8e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd1a7f1 dce_masking-none elementor-widget elementor-widget-image\" data-id=\"fd1a7f1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/nicoletcz.cz\/en\/product\/dxr3xi-microscope\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/nicoletcz.cz\/app\/uploads\/elementor\/thumbs\/ad9a46d8-pwomdegm3bgs3btcs91xhengh8mt7e6lc2q4lqa0fs.jpg\" title=\"DXRxiCover-1920&#215;1080\" alt=\"DXRxiCover-1920x1080\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-88ad3bd\" data-id=\"88ad3bd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d504789 elementor-widget elementor-widget-heading\" data-id=\"d504789\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/nicoletcz.cz\/en\/product\/dxr3xi-microscope\/\">DXR3xi Microscope<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-11ea6dc elementor-widget elementor-widget-text-editor\" data-id=\"11ea6dc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tThe user-proven DXR Raman microscope is now available in the new version of the DXR3xi with a high-performance EMCCD detector and a microscopic table with the possibility of nanoslift for super fast Chemical Imaging of your samples.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div><!-- end wrapper -->\n\n\t\t\t\t\t<\/div><!-- end item -->\n\n\t\t\t\t\t\n\t\t\t<\/div><!-- end grid -->\n\n\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t                    <\/div>\n\t\t        \n                    <div id=\"other-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"other-tab\">\n\t\t\t\t        <ol>\n<li>Richard L. McCreery. <em>Raman Spectroscopy for Chemical Analysis<\/em> <br \/>ISBN: 0-471-23187-8 WILEY<\/li>\n<li>M. Hor\u00e1k, D. Papou\u0161ek a kol.Infrared spectra and structure of molecules <em>,<br \/><\/em>Academia, Praha 1974.<\/li>\n<li>Guillory P., Deschaines T., Henson P. <em>Confocal Raman microscopy analysis of multilayer polymer films<\/em>, Thermo Scientific Application Note 51718, 2008.<\/li>\n<li>Mohammed Ibrahim, Ph.D. Confocal Raman analysis of a transdermal nicotine patch by a DXR2 Raman Microscope Thermo Scientific APPLICATION NOTE AN52984, 2008<\/li>\n<\/ol>\n                    <\/div>\n\t\t                    <\/div>\n        <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Application description Raman spectroscopy Other Transdermal patchesare one way to provide a controlled release of drugs through the skin into the bloodstream via controlled release. Nicotine patchesare one form of treatment for nicotine addiction. The nicotine transdermal patch itself consists of several layers: a protective layer, an adhesive layer, a membrane and a protective pad. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":3041,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9303","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Analysis of nicotine patches - NicoletCZ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analysis of nicotine patches - NicoletCZ\" \/>\n<meta property=\"og:description\" content=\"Application description Raman spectroscopy Other Transdermal patchesare one way to provide a controlled release of drugs through the skin into the bloodstream via controlled release. Nicotine patchesare one form of treatment for nicotine addiction. The nicotine transdermal patch itself consists of several layers: a protective layer, an adhesive layer, a membrane and a protective pad. [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/\" \/>\n<meta property=\"og:site_name\" content=\"NicoletCZ\" \/>\n<meta property=\"article:modified_time\" content=\"2021-10-06T12:13:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/78d00216-300x231.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/\",\"url\":\"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/\",\"name\":\"Analysis of nicotine patches - NicoletCZ\",\"isPartOf\":{\"@id\":\"https:\/\/nicoletcz.cz\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/78d00216-300x231.jpg\",\"datePublished\":\"2021-10-06T12:13:07+00:00\",\"dateModified\":\"2021-10-06T12:13:52+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/#primaryimage\",\"url\":\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/78d00216-300x231.jpg\",\"contentUrl\":\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/78d00216-300x231.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Dom\u016f\",\"item\":\"https:\/\/nicoletcz.cz\/en\/main-page\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Applications\",\"item\":\"https:\/\/nicoletcz.cz\/en\/solutions\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Pharmacy and medicine\",\"item\":\"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Analysis of nicotine patches\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/nicoletcz.cz\/#website\",\"url\":\"https:\/\/nicoletcz.cz\/\",\"name\":\"NicoletCZ\",\"description\":\"Molekulov\u00e1 spektroskopie\",\"publisher\":{\"@id\":\"https:\/\/nicoletcz.cz\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/nicoletcz.cz\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/nicoletcz.cz\/#organization\",\"name\":\"NicoletCZ\",\"url\":\"https:\/\/nicoletcz.cz\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/nicoletcz.cz\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/01\/4b6cb9bb.svg\",\"contentUrl\":\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/01\/4b6cb9bb.svg\",\"width\":180,\"height\":34,\"caption\":\"NicoletCZ\"},\"image\":{\"@id\":\"https:\/\/nicoletcz.cz\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Analysis of nicotine patches - NicoletCZ","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/","og_locale":"en_US","og_type":"article","og_title":"Analysis of nicotine patches - NicoletCZ","og_description":"Application description Raman spectroscopy Other Transdermal patchesare one way to provide a controlled release of drugs through the skin into the bloodstream via controlled release. Nicotine patchesare one form of treatment for nicotine addiction. The nicotine transdermal patch itself consists of several layers: a protective layer, an adhesive layer, a membrane and a protective pad. [&hellip;]","og_url":"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/","og_site_name":"NicoletCZ","article_modified_time":"2021-10-06T12:13:52+00:00","og_image":[{"url":"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/78d00216-300x231.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/","url":"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/","name":"Analysis of nicotine patches - NicoletCZ","isPartOf":{"@id":"https:\/\/nicoletcz.cz\/#website"},"primaryImageOfPage":{"@id":"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/#primaryimage"},"image":{"@id":"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/#primaryimage"},"thumbnailUrl":"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/78d00216-300x231.jpg","datePublished":"2021-10-06T12:13:07+00:00","dateModified":"2021-10-06T12:13:52+00:00","breadcrumb":{"@id":"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/#primaryimage","url":"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/78d00216-300x231.jpg","contentUrl":"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/09\/78d00216-300x231.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/analysis-of-nicotine-patches\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Dom\u016f","item":"https:\/\/nicoletcz.cz\/en\/main-page\/"},{"@type":"ListItem","position":2,"name":"Applications","item":"https:\/\/nicoletcz.cz\/en\/solutions\/"},{"@type":"ListItem","position":3,"name":"Pharmacy and medicine","item":"https:\/\/nicoletcz.cz\/en\/solutions\/pharmacy-and-medicine\/"},{"@type":"ListItem","position":4,"name":"Analysis of nicotine patches"}]},{"@type":"WebSite","@id":"https:\/\/nicoletcz.cz\/#website","url":"https:\/\/nicoletcz.cz\/","name":"NicoletCZ","description":"Molekulov\u00e1 spektroskopie","publisher":{"@id":"https:\/\/nicoletcz.cz\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/nicoletcz.cz\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/nicoletcz.cz\/#organization","name":"NicoletCZ","url":"https:\/\/nicoletcz.cz\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nicoletcz.cz\/#\/schema\/logo\/image\/","url":"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/01\/4b6cb9bb.svg","contentUrl":"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/01\/4b6cb9bb.svg","width":180,"height":34,"caption":"NicoletCZ"},"image":{"@id":"https:\/\/nicoletcz.cz\/#\/schema\/logo\/image\/"}}]}},"acf":[],"_links":{"self":[{"href":"https:\/\/nicoletcz.cz\/en\/wp-json\/wp\/v2\/pages\/9303","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nicoletcz.cz\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nicoletcz.cz\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nicoletcz.cz\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nicoletcz.cz\/en\/wp-json\/wp\/v2\/comments?post=9303"}],"version-history":[{"count":3,"href":"https:\/\/nicoletcz.cz\/en\/wp-json\/wp\/v2\/pages\/9303\/revisions"}],"predecessor-version":[{"id":9306,"href":"https:\/\/nicoletcz.cz\/en\/wp-json\/wp\/v2\/pages\/9303\/revisions\/9306"}],"up":[{"embeddable":true,"href":"https:\/\/nicoletcz.cz\/en\/wp-json\/wp\/v2\/pages\/3041"}],"wp:attachment":[{"href":"https:\/\/nicoletcz.cz\/en\/wp-json\/wp\/v2\/media?parent=9303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}