{"id":10421,"date":"2022-01-10T13:05:44","date_gmt":"2022-01-10T13:05:44","guid":{"rendered":"https:\/\/nicoletcz.cz\/solutions\/science-research-education\/immunotherapy-research-using-raman-spectroscopy\/"},"modified":"2022-01-10T13:05:46","modified_gmt":"2022-01-10T13:05:46","slug":"immunotherapy-research-using-raman-spectroscopy","status":"publish","type":"page","link":"https:\/\/nicoletcz.cz\/en\/solutions\/science-research-education\/immunotherapy-research-using-raman-spectroscopy\/","title":{"rendered":"Immunotherapy research using Raman spectroscopy"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"10421\" class=\"elementor elementor-10421 elementor-10045\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-129dd02 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"129dd02\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e622935\" data-id=\"e622935\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b2f1837 elementor-widget elementor-widget-eael-adv-tabs\" data-id=\"b2f1837\" data-element_type=\"widget\" data-widget_type=\"eael-adv-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div data-scroll-on-click=\"no\" data-scroll-speed=\"300\" id=\"eael-advance-tabs-b2f1837\" class=\"eael-advance-tabs eael-tabs-horizontal eael-tab-auto-active  active-caret-on responsive-vertical-layout\" data-tabid=\"b2f1837\">\n            <div class=\"eael-tabs-nav\">\n                <ul class=\"\" role=\"tablist\">\n                                            <li id=\"application-description\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"application-description-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Application description<\/span>                                                    <\/li>\n                                            <li id=\"raman-spectroscopy\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"raman-spectroscopy-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Raman spectroscopy<\/span>                                                    <\/li>\n                                            <li id=\"snom\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"snom-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >SNOM<\/span>                                                    <\/li>\n                                    <\/ul>\n            <\/div>\n            \n            <div class=\"eael-tabs-content\">\n\t\t        \n                    <div id=\"application-description-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"application-description-tab\">\n\t\t\t\t        <p><a href=\"https:\/\/www.azom.com\/article.aspx?ArticleID=21025&amp;CID=CMP-03930-S8D4&amp;utm_source=Comms-Employee+Advocacy&amp;es_id=6337c18d2e\">The first application<\/a> to evaluate biochemical changes in malignancies treated by immunotherapy using Raman spectroscopy (Nature publication to <a href=\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/12\/89af98b0.pdf\">download here<\/a>) was developed by a research team from the University of Arkansas.<\/p>\n<p>Immunotherapy, unlike other therapeutic approaches, does not always lead to immediate and predictable suppression of tumor growth. There is also currently no reliable way to evaluate a patient&#8217;s response to treatment. At the same time, only a small proportion of patients respond to treatment and a large number of selected immunosuppressants have serious side effects.<\/p>\n<p>Raman spectroscopy is a <strong>fast, non-destructive and reliable method of analysis<\/strong> that does not require any labeling of molecules. It is a powerful tool that can improve diagnostic accuracy through deep insight into the biochemical changes that occur in cancer tissue.<\/p>\n<p>In this pilot study, Raman spectroscopic imaging was used to diagnose and classify chondrogenic tumors, including advanced enchondromas and chondrosarcomas.<\/p>\n<p><strong><u>Raman spectroscopy techniques<\/u><\/strong><\/p>\n<p><strong><a href=\"https:\/\/nicoletcz.cz\/en\/model-series\/raman-spectroscopy\/\">Raman spectroscopy<\/a><\/strong> was used here to evaluate the molecular composition of colon cancer tumors in mice treated with two types of immunotherapeutic drugs that are now used in clinical treatment.<\/p>\n<p>Hundreds of Raman spectra of these tumors treated with various immunotherapeutic procedures were measured, which were then used as input data for machine learning algorithms.<\/p>\n<p>The data from each tumor were then compared to all available data to see if there was a difference between tumors that received different forms of immunotherapy and tumors that remained untreated. It was found that the method is able to detect even early forms of tumors.<\/p>\n<p><strong><u>Cancer diagnosis using Raman spectroscopy<\/u><\/strong><\/p>\n<p>Cancer diagnosis has long been one of the most difficult tasks in medicine, and it is Raman spectroscopy that is becoming increasingly important in detecting the chemical composition of tissues and cells as new non-invasive procedures are developed or old ones are improved.<\/p>\n<p>Raman spectroscopy has revealed pathological abnormalities in bone matrix components and is also used to analyze common bone biochemical characteristics. These changes include modifications in the breakdown of phosphates, carbonates and collagen, as well as spectral modifications in bone metastases caused by prostate or breast cancer.<\/p>\n<p>The formation of calcifications was also confirmed by topographic analysis, which is consistent with the histological morphology of cartilaginous tumors, which usually reveal amorphous calcium deposits and ossification. In rare cases, excessive bone development can lead to misdiagnosis of osteosarcoma.<\/p>\n<p>Even in this case, Raman spectroscopy has proven to be a powerful diagnostic tool.<\/p>\n<p><strong><u>Proline detection by Raman spectroscopy<\/u><\/strong><\/p>\n<p>Proline is an essential amino acid for collagen production. The degree of malignancy seems to be closely linked to the numerous biochemical processes, such as the collagen breakdown, which is the source of the increased proline content, cell proliferation or variable biochemical composition of non-collagenous proteins with respect to proteoglycan content.<\/p>\n<p>These processes are another argument for the versatile use of Raman spectroscopy in this field.<\/p>\n                    <\/div>\n\t\t        \n                    <div id=\"raman-spectroscopy-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"raman-spectroscopy-tab\">\n\t\t\t\t        <style>@media(max-width:1024px){.elementor-6769 .elementor-element.elementor-element-8179397 .dce-post-item{padding:0px 0px 20px 0px;}}@media(max-width:767px){.elementor-6769 .elementor-element.elementor-element-8179397 .dce-post-item{padding:0px 0px 15px 0px;}}<\/style>\t\t<div data-elementor-type=\"section\" data-elementor-id=\"6769\" class=\"elementor elementor-6769 elementor-4972\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-aa1571b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"aa1571b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4f9ab22\" data-id=\"4f9ab22\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"dce-fix-background-loop elementor-element elementor-element-8179397 templatemode-yes elementor-widget elementor-widget-dyncontel-acfposts\" data-id=\"8179397\" data-element_type=\"widget\" data-widget_type=\"dyncontel-acfposts.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"acfposts-grid dce-posts-wrap simple-style\" data-style=\"simple\">\n\n\t\t\t\t\n\t\t\t\t\t<div data-dce-post-id=\"6678\" class=\"dce-post-item dce-post-item-6678 dce-elementor-6678 elementor-1449 column-  \">\n\n\t\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"dce-wrapper \">\n\n\t\t\t\t\t\t\t\t\t<div data-elementor-type=\"single-post\" data-elementor-id=\"6765\" class=\"elementor elementor-6765 dce-elementor-rendering-id-1 elementor-4983\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2bad051 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2bad051\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0824a49\" data-id=\"0824a49\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-34b4766 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"34b4766\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-699df8e\" data-id=\"699df8e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd1a7f1 dce_masking-none elementor-widget elementor-widget-image\" data-id=\"fd1a7f1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/nicoletcz.cz\/en\/product\/dxr3-microscope\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/nicoletcz.cz\/app\/uploads\/elementor\/thumbs\/46cdeec8-pv2c07lcqh9qz7lya5meayoidxjpy2w41w8yc7yda0.jpg\" title=\"DXXmikr1-468&#215;405 (1)\" alt=\"DXXmikr1-468x405 (1)\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-88ad3bd\" data-id=\"88ad3bd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d504789 elementor-widget elementor-widget-heading\" data-id=\"d504789\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/nicoletcz.cz\/en\/product\/dxr3-microscope\/\">DXR3 Microscope<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-11ea6dc elementor-widget elementor-widget-text-editor\" data-id=\"11ea6dc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tThe Nicolet DXR3 Dispersi Raman Microscope is an instrument designed for applications requiring high spatial resolution, ease of sample preparation, and the use of the strongpoints of Raman microscopy.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div><!-- end wrapper -->\n\n\t\t\t\t\t<\/div><!-- end item -->\n\n\t\t\t\t\t\n\t\t\t\t\t<div data-dce-post-id=\"6673\" class=\"dce-post-item dce-post-item-6673 dce-elementor-6673 elementor-1451 column-  \">\n\n\t\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"dce-wrapper \">\n\n\t\t\t\t\t\t\t\t\t<div data-elementor-type=\"single-post\" data-elementor-id=\"6765\" class=\"elementor elementor-6765 dce-elementor-rendering-id-2 elementor-4983\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2bad051 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2bad051\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0824a49\" data-id=\"0824a49\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-34b4766 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"34b4766\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-699df8e\" data-id=\"699df8e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd1a7f1 dce_masking-none elementor-widget elementor-widget-image\" data-id=\"fd1a7f1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/nicoletcz.cz\/en\/product\/dxr3xi-microscope\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/nicoletcz.cz\/app\/uploads\/elementor\/thumbs\/ad9a46d8-pwomdegm3bgs3btcs91xhengh8mt7e6lc2q4lqa0fs.jpg\" title=\"DXRxiCover-1920&#215;1080\" alt=\"DXRxiCover-1920x1080\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-88ad3bd\" data-id=\"88ad3bd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d504789 elementor-widget elementor-widget-heading\" data-id=\"d504789\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/nicoletcz.cz\/en\/product\/dxr3xi-microscope\/\">DXR3xi Microscope<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-11ea6dc elementor-widget elementor-widget-text-editor\" data-id=\"11ea6dc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tThe user-proven DXR Raman microscope is now available in the new version of the DXR3xi with a high-performance EMCCD detector and a microscopic table with the possibility of nanoslift for super fast Chemical Imaging of your samples.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div><!-- end wrapper -->\n\n\t\t\t\t\t<\/div><!-- end item -->\n\n\t\t\t\t\t\n\t\t\t<\/div><!-- end grid -->\n\n\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t                    <\/div>\n\t\t        \n                    <div id=\"snom-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"snom-tab\">\n\t\t\t\t        <style>@media(max-width:1024px){.elementor-6756 .elementor-element.elementor-element-43f4b2a9 .dce-post-item{padding:0px 0px 20px 0px;}}@media(max-width:767px){.elementor-6756 .elementor-element.elementor-element-43f4b2a9 .dce-post-item{padding:0px 0px 15px 0px;}}<\/style>\t\t<div data-elementor-type=\"section\" data-elementor-id=\"6756\" class=\"elementor elementor-6756 elementor-5032\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-66c51c3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"66c51c3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-34ebf637\" data-id=\"34ebf637\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t                    <\/div>\n\t\t                    <\/div>\n        <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Application description Raman spectroscopy SNOM The first application to evaluate biochemical changes in malignancies treated by immunotherapy using Raman spectroscopy (Nature publication to download here) was developed by a research team from the University of Arkansas. Immunotherapy, unlike other therapeutic approaches, does not always lead to immediate and predictable suppression of tumor growth. There is [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":10047,"parent":3069,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-10421","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Immunotherapy research using Raman spectroscopy - NicoletCZ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nicoletcz.cz\/en\/solutions\/science-research-education\/immunotherapy-research-using-raman-spectroscopy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immunotherapy research using Raman spectroscopy - NicoletCZ\" \/>\n<meta property=\"og:description\" content=\"Application description Raman spectroscopy SNOM The first application to evaluate biochemical changes in malignancies treated by immunotherapy using Raman spectroscopy (Nature publication to download here) was developed by a research team from the University of Arkansas. Immunotherapy, unlike other therapeutic approaches, does not always lead to immediate and predictable suppression of tumor growth. There is [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nicoletcz.cz\/en\/solutions\/science-research-education\/immunotherapy-research-using-raman-spectroscopy\/\" \/>\n<meta property=\"og:site_name\" content=\"NicoletCZ\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-10T13:05:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nicoletcz.cz\/app\/uploads\/2021\/12\/27c151a3.png\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"640\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/nicoletcz.cz\/en\/solutions\/science-research-education\/immunotherapy-research-using-raman-spectroscopy\/\",\"url\":\"https:\/\/nicoletcz.cz\/en\/solutions\/science-research-education\/immunotherapy-research-using-raman-spectroscopy\/\",\"name\":\"Immunotherapy research using Raman spectroscopy - 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